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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RRM2
All Species:
50.91
Human Site:
Y183
Identified Species:
80
UniProt:
P31350
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31350
NP_001025.1
389
44878
Y183
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100144
351
40744
K167
E
T
M
P
Y
V
K
K
K
A
D
W
A
L
R
Dog
Lupus familis
XP_540076
394
45449
Y188
Y
S
L
L
I
D
T
Y
I
K
D
S
K
E
R
Cat
Felis silvestris
Mouse
Mus musculus
P11157
390
45077
Y184
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
R
Rat
Rattus norvegicus
Q4KLN6
390
45020
Y184
Y
S
L
L
I
D
T
Y
I
K
D
S
K
E
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506085
394
45462
Y188
Y
S
L
L
I
D
T
Y
I
K
E
P
K
E
R
Chicken
Gallus gallus
XP_419948
384
44421
Y178
Y
S
L
L
I
D
T
Y
I
K
D
S
K
E
R
Frog
Xenopus laevis
NP_001080772
386
44577
Y180
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
R
Zebra Danio
Brachydanio rerio
P79733
386
44575
Y180
Y
S
L
L
I
D
T
Y
I
K
D
S
K
E
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48592
393
45096
Y187
Y
S
V
L
I
D
T
Y
I
R
D
P
H
Q
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42170
381
44271
Y175
Y
S
K
L
I
E
T
Y
I
R
D
E
T
E
R
Sea Urchin
Strong. purpuratus
XP_780110
412
47263
Y201
Y
S
L
L
I
D
T
Y
I
K
D
S
V
Q
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q6Y657
333
38312
M149
T
K
K
A
E
W
A
M
K
W
I
N
G
S
Q
Baker's Yeast
Sacchar. cerevisiae
P09938
399
46129
Y190
Y
S
L
L
I
D
T
Y
I
K
D
P
K
E
S
Red Bread Mold
Neurospora crassa
Q9C167
410
46679
Y191
Y
S
L
L
I
D
T
Y
I
K
E
P
S
Q
R
Conservation
Percent
Protein Identity:
100
N.A.
72.4
95.4
N.A.
91.2
89.7
N.A.
90.6
88.4
84
83.5
N.A.
68.9
N.A.
59.9
67.9
Protein Similarity:
100
N.A.
82
96.4
N.A.
95.3
94.6
N.A.
95.4
94
91
90.7
N.A.
79.3
N.A.
74.8
77.6
P-Site Identity:
100
N.A.
13.3
93.3
N.A.
100
93.3
N.A.
93.3
93.3
100
93.3
N.A.
73.3
N.A.
66.6
80
P-Site Similarity:
100
N.A.
26.6
93.3
N.A.
100
93.3
N.A.
100
93.3
100
93.3
N.A.
93.3
N.A.
80
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
58.8
58.4
64.3
Protein Similarity:
N.A.
N.A.
N.A.
69.9
71.4
75.8
P-Site Identity:
N.A.
N.A.
N.A.
0
93.3
80
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
93.3
93.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
7
0
0
7
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
80
0
0
0
0
80
0
0
0
0
% D
% Glu:
7
0
0
0
7
7
0
0
0
0
14
7
0
67
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
0
0
87
0
0
0
87
0
7
0
0
0
0
% I
% Lys:
0
7
14
0
0
0
7
7
14
74
0
0
60
0
0
% K
% Leu:
0
0
74
87
0
0
0
0
0
0
0
0
0
7
0
% L
% Met:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
7
0
0
0
0
0
0
0
47
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
20
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
14
0
0
0
0
87
% R
% Ser:
0
87
0
0
0
0
0
0
0
0
0
34
7
7
7
% S
% Thr:
7
7
0
0
0
0
87
0
0
0
0
0
7
0
0
% T
% Val:
0
0
7
0
0
7
0
0
0
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
7
0
0
0
7
0
7
0
0
0
% W
% Tyr:
87
0
0
0
7
0
0
87
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _